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Pediatric Bone Marrow Transplant (BMT)

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Pediatric Bone Marrow Transplant (BMT)

Bone Marrow Transplant (BMT)

Post Graduate Institute of Child Health

Noida

About PGICH, Noida

The Post Graduate Institute of Child Health (PGICH), Noida is a premier tertiary care and academic institute dedicated exclusively to children.

  • Established as a State Institute under Government of Uttar Pradesh, it serves children from across the state and beyond.
  • Offers specialized pediatric services across pediatrics, neonatology, hematology and oncology, cardiology, pediatric surgery, cardiac surgery etc.
  • Functions as a teaching and research center, training the next generation of pediatric specialists.
  • Committed to affordable, high-quality care for all children, regardless of background.


# Title Details
1 Souvenir released in Jan 2025, on the occasion of the inauguration of the new BMT unit at PGICH by Hon. Deputy Chief Minister, Uttar Pradesh Shri Brijesh Pathak

What is BMT?

A Bone Marrow Transplant (BMT), also called a Hematopoietic Stem Cell Transplant (HSCT), is a life-saving procedure in which damaged or diseased bone marrow is replaced with healthy stem cells.

  • The bone marrow is the factory inside our bones that produces blood cells.
  • In many childhood blood disorders, this factory stops working properly.
  • A BMT helps restore healthy blood cell production, improving immunity, oxygen carrying capacity, and clotting functions. 

There are two main types:

  • Autologous BMT: Child’s own stem cells are collected and given back after treatment.
Allogeneic BMT: Stem cells come from a matched donor (sibling, unrelated donor, or cord blood, mismatched family member)


# Title Details
1 Living and Winning – Find answers to 100 questions on BMT from the team at PGICH

Indications in Pediatrics

BMT is an established treatment for several serious childhood diseases:

Blood Cancers

  • Acute Lymphoblastic Leukemia (ALL) – high-risk or relapsed
  • Acute Myeloid Leukemia (AML) – high-risk or relapsed
  • Chronic Myeloid Leukemia (CML) – resistant to medicines

Bone Marrow Failure Syndromes

  • Aplastic Anemia (severe/refractory)
  • Fanconi Anemia
  • Congenital Amegakaryocytic Thrombocytopenia (CAMT)
  • Dyskeratosis congenita
  • Severe congenital neutropenia

Inherited Disorders

  • Thalassemia Major
  • Sickle Cell Disease (recurrent crises/complications)
  • Transfusion dependent anemias – Pyruvate Kinase deficiency, Congenital Dyserythropoietic anemia etc
  • Immunodeficiency disorders (e.g., SCID, WAS, HLH)
  • Metabolic disorders (e.g., Hurler syndrome, Adrenoleukodystrophy)

What to Do if Your Child Needs BMT

If your child is advised BMT at PGICH:

  1. Initial Consultation
    • Meet the PHO-BMT team for detailed assessment.
    • Understand disease status, type of BMT needed
  2. Donor Search
    • Siblings are tested first (HLA typing).
    • If no match, unrelated donor registries or haploidentical donor from family is taken
  3. Pre-Transplant Work-up
    • Medical fitness tests for child and donor.
    • Infection screening and counseling sessions.
  4. Admission & Transplant
    • The child stays in a specialized isolation room.
    • High-dose chemotherapy (and sometimes radiation) is given before transplant.
  5. Stem cell apheresis
    • Stem cells are collected from the donor, by peripheral blood stem cell apheresis in the blood center
    • Stem cells product may need modification / cryopreservation in certain scenarios
  6. Post-Transplant Care
    • Stem cells are infused intravenously like a blood transfusion.
    • Close monitoring for infections, graft-versus-host disease (GVHD), and recovery.
    • Regular follow-up for months to years

Funding Support

BMT is resource-intensive, but support is available:

  • Government Schemes: PM relief fund, CM relief fund, other State Health Programs.
  • Charitable Trusts/NGOs: Bridge support till government funding is obtained.

The PHO-BMT social support team at PGICH helps families identify the best funding options.

Details of the BMT Unit at PGICH

  • Dedicated Pediatric BMT Facility with HEPA-filtered rooms for infection-free care.
  • Multidisciplinary Team: Faculty and residents in Pediatric Hematology Oncology, faculty in transfusion medicine, nurses, dieticians, BMT coordinator and support staff
  • Infection Control Measures: Strict hygiene, filtered air circulation, specialized nursing protocols.
Regular family Counseling: Emotional and psychological support before, during, and after transplant.


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